Biologics for the Treatment of Asthma

Biologics have emerged as a groundbreaking treatment option for moderate-to-severe asthma that doesn't respond well to traditional medications like inhalers or corticosteroids. By targeting specific molecules and immune pathways, biologic treatments effectively reduce inflammation, providing relief for patients who experience frequent asthma symptoms. Allergy & Asthma Associates of Michigan offers biologic treatments for our patients in Royal Oak, MI and the surrounding areas. We'll give you an overview of biologics for asthma, including how they work, who qualifies, the available options, and what to expect.

What Are Biologic Treatments?

Biologic treatments are advanced medications derived from living organisms like bacteria or plant cells. They have become the mainstay in many fields of respiratory disease and autoimmune disorders. These treatments are designed to target specific molecules or immune system pathways that cause inflammation in conditions like asthma. Unlike traditional asthma medications that provide broad symptom relief, biologic injections for asthma focus on the root cause of inflammation, making them highly effective and targeted therapy.

How Do Biologics Treat Asthma?

When asthma triggers, such as allergens, irritants or viral particles, are introduced, they activate specific immune system responses that lead to airway swelling, mucus production, and breathing difficulties. Biologics act by:

• Blocking specific molecules that cause inflammation. 

• Disrupting pathways that play a role in asthma flares. 

• Preventing immune system reactions that contribute to airway narrowing and mucus overproduction. 

Who Qualifies for Biologic Therapy?

Biologics are typically recommended for individuals with moderate-to-severe asthma who don't respond well to standard treatments. We will review your medical history, current medications, and blood test results to determine if biologics are suitable for you. You might qualify for biologic therapy if:

• You experience frequent asthma symptoms despite the proper use of medications. 

• Your asthma leads to nighttime awakenings or impacts daily activities. 

• You require oral corticosteroids multiple times a year. 

• You frequently visit the emergency room or need hospitalization due to asthma. 

• Blood tests indicate high levels of eosinophils or IgE antibodies (markers of inflammation).

Types of Biologics for Asthma

There are six FDA-approved biologics available for the treatment of asthma, each targeting specific immune pathways. Here's a quick overview:

• Xolair: Xolair for asthma treats allergic asthma by targeting IgE antibodies, which trigger airway tightening in response to allergens like dust or pollen.

• Nucala: Nucala for asthma targets IL-5 to reduce eosinophil-driven inflammation in eosinophilic asthma.

• Cinqair: Cinqair for asthma blocks IL-5 and is administered through IV infusions for eosinophilic asthma.

• Fasenra: Fasenra for asthma reduces eosinophil levels by targeting their IL-5 receptors.

• Dupixent: Dupixent for asthma is effective for asthma treatments, eosinophilic and oral corticosteroid-dependent asthma, as it blocks IL-4 and IL-13 proteins.

• Tezspire: The latest biologic, Tezspire for asthma is designed to treat type 2 (allergic and eosinophilic) and non-type 2 asthma by targeting TSLP molecules.

Benefits of Biologics for Asthma

Biologic treatments have been a game-changer for many asthma sufferers. Some of the most significant benefits of biologics for asthma include:

• Significant reduction in asthma symptoms and episodes. 

• Improved lung function and easier breathing. 

• Fewer emergency room visits for asthma-related complications. 

• Decreased need for oral corticosteroids and other medications. 

• Enhanced quality of life, allowing you to engage in activities more freely.  

Potential Side Effects

While biologics are generally safe, some people may experience mild side effects. Some of the most common side effects of biologics include:

• Headache, fatigue, or joint pain. 

• Reaction at the injection site.  

• Sore throat or back pain. 

• Uncommonly seen, but anaphylaxis is a black box warning with Xolair 

Recovery and Outlook

Biologics are not an instant fix. It may take weeks or months to experience noticeable improvements in asthma symptoms. Most patients begin to see positive changes within three to six months, with a gradual reduction in the frequency and severity of asthma episodes. Long-term use under medical supervision ensures better symptom management and can potentially lead to a lower reliance on traditional asthma medications like inhaled corticosteroids.

Role of Asthma Inhalers with Biologics

Biologics work as add-on therapies. This means they complement, rather than replace, traditional asthma treatments. It's crucial to continue using prescribed inhalers alongside biologic therapy to manage day-to-day symptoms effectively. Over time, we may adjust inhaler usage based on how well your asthma responds to the biologic.

Insurance Coverage for Biologic Treatments

Biologics are advanced, specialized medications, and their cost can be significant. Luckily, many insurance companies cover biologics for severe asthma treatment, although prior authorization may be required. Additionally, some pharmaceutical companies offer assistance programs to help offset out-of-pocket costs for uninsured or underinsured patients.

Explore Biologics for Asthma Today

Let Allergy & Asthma Associates of Michigan help you take charge of asthma. Biologics are a revolutionary step forward in asthma treatment, offering hope for those who struggle with moderate-to-severe asthma symptoms. With targeted, personalized medicine, the future is brighter for individuals seeking long-term relief and a better quality of life. Contact us today to schedule a consultation at our convenient locations.